Factor XIIIa rapidly cross-links α2-antiplasmin to the α-chain of fibrin.67,68 This cross-linking reaction occurs between Gln2 in the amino terminus of α2-antiplasmin69 and Lys303 in the fibrin α-chain.68 The α2-antiplasmin remains an efficient plasmin inhibitor when covalently cross-linked to fibrin, and incorporation of the inhibitor into the clot by factor XIII plays a major role in

Enhanced activation of proinflammatory factors via protease-activated receptors (PARs); Activation of factor XIII to factor XIIIa, which augments production of fibrin

Species. Homo sapiens. Synonyms: Coagulation factor XIII A chain, Coagulation factor XIIIa, F13A, Protein -glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain. Coagulation factor XIII A chain; Coagulation factor XIII A1 polypeptide; Coagulation factor XIIIa; F13A; F13a1; Factor XIIIA; Fibrin stabilizing factor, A subunit; 1 Feb 2021 Factor XIII-A deficiency is mainly caused by mutations in the FXIII-A gene (95% of cases) [28]; while homozygous mutations usually result in 24 May 2008 Factor XIIIa. Factor XIII is a proenzyme with a role in blood coagulation. Immunohistochemical expression.

The case of a baby is reported who showed typical clinical features Newcomer Supply Factor XIIIa (fibrin stabilizing factor) Control Slides are for the positive immunohistochemical staining of Factor XIIIa, a blood coagulation 24 May 2008 Factor XIIIa. Factor XIII is a proenzyme with a role in blood coagulation. Immunohistochemical expression. megakaryocytes. Define Factor xiiia. Factor xiiia synonyms, Factor xiiia pronunciation, Factor xiiia translation, English dictionary definition of Factor xiiia.

Amplifiering. XIII. Propagering.

To assess the use of anti-CD34 and anti-factor-XIIIa antibodies for the differential diagnosis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP), we stained 40 DFs and 13 DFSPs. A significant population of dendritic and spindle cells was reactive with anti-factor-XIIIa in 90% of DFs.

Factor XIII (FXIII), or fibrin stabilizing factor, deficiency was first reported in the literature in 1960. It is the rarest factor deficiency, occurring in 1 per 5 million births.

This study describes the changes in number and distribution of somatostatin- and factor XIIIa-immunoreactive dendritic cells in the epidermis and dermis of

Cited in 1 reference(s). Definition / general Fibrohistiocytic marker; note that peritumoral cells may also exhibit Factor XIIIa staining Also active form of factor XIII, an enzyme of coagulation system that crosslinks fibrin (Wikipedia: Factor XIII [Accessed 2 August 2018]) Stabilization of Fibrin The conversion of soluble fibrin to an insoluble fibrin clot is catalyzed by the transamidase factor XIIIa. Lysine and glutamine side chains of α- and γ-chains of fibrin are crosslinked to form homopolymers. HCXIIIA-0165 Human Factor XIIIa Price $259.00/50 µg ($238.00/min. 5) Factor XIIIa is a blood coagulation prototransglutaminase 1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca 2+.

Cat.No. 66325-1-Ig. Both spindle and pleomorphic tumor cells are consistently positive for vimentin, with varied expression of CD34, factor XIIIa, VEGF, and CD99, but are negative for S100 protein, cytokeratin, desmin, epithelial membrane antigen, smooth muscle actin, HMB-45, MyoD1, p63, and CD31 (determined by immunohistochemistry). Synonyms for Factor xiiia in Free Thesaurus. Antonyms for Factor xiiia. 1 synonym for factor XIII: fibrinase.
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Factor XIIIa is a blood coagulation prototransglutaminase 1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca 2+.
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The goal of this study was to examine how plasma levels of factor V, VIII, XIIIa, von Willebrand factor antigen (vWF:Ag), fibrinogen, thrombomodulin evolve from

+ AT III. av E Bäck · 2018 — sampling is the preanalytic factor that most affects hemostasis tests and where the Proenzymet faktor XIII aktiveras av trombin till faktor XIIIa. Hypoxi → Hypoxia inducible factor (HIF) → Erytropoietin klyver stabiliseringsfaktor XIII till XIIIa, som tillsammans med Ca2+ bildar cross-links (kp1), ham56, mac 387, factor xiiia, enzymes (lysozyme, alpha antitryps) What does AE1 detect. All acidic CKs except ck9, 12, 17,18. Which cytokeratin is not.

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Factor XIII is activated by thrombin to form an active transglutaminase enzyme, factor XIIIa. Factor XIIIa introduces cross-links between fibrin-fibrin strands. It also cross-links inhibitors of fibrinolysis, specifically α 2 AP, 126 TAFI, 127 and PAI-2 128 to fibrin.

It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. Signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot.

Rheumatoid factor (RF) and antibodies against citrullinated proteins/peptides (ACPA) plasminogen activator inhibitor type-1 (PAI-1) (4G/5G) and Factor XIIIA

Factor XIIIa, also known as fibrinoligase and fibrin-stabilizing factor, is the last enzyme generated in the blood coagulation cascade. Notably, we show that IMs highly express Factor XIIIA, which promotes fibrin cross-linking to create a scaffold for LUSC cell invasion and metastases. Consistently, human LUSC samples containing extensive cross-linked fibrin in the microenvironment correlated with poor survival. Factor XIII (FXIII) is a key molecule in the field of blood coagulation and in the last decades it has weakened attention within the field of angiogenesis and tissue repair. FXIII positively influences wound healing in several tissues by exerting multiple plasma and cellular functions.

They are identified in close association with blood Factor XIIIa is a blood proenzyme that has been identified in platelets, megakaryocyte, and fibroblast-like mesenchymal or histiocytic cells present in the placenta, uterus, and prostate; it is also present in monocytes and macrophages and dermal dendritic cells. Factor XIII is activated by thrombin in the presence of calcium which leads to the release of the activation peptide, followed by the dissociation of carrier subunits.